O-glipron is a non-peptide, small-molecule GLP-1 receptor agonist. Molecular formula C48H48F2N10O5, molecular weight 882.97 g/mol.
Unlike peptide-based GLP-1R agonists, O-glipron is chemically stable in acidic environments and resists proteolytic degradation. These properties make it a relevant tool for studying small-molecule receptor activation in cellular assays.
It acts as a partial agonist at the GLP-1 receptor, with documented biased signaling toward G protein-mediated cAMP accumulation over β-arrestin recruitment. This receptor bias reduces internalization activity, a mechanistic distinction of interest in GLP-1R signaling research. EC₅₀ values in the low nanomolar range (~0.5–1 nM) have been reported in cAMP accumulation assays using HEK293 cells expressing GLP-1R.
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Every Limitless Biotech Standard Non-Lyophilized compound undergoes independent third-party HPLC purity testing as part of our systematic quality protocols.
For research use only.
- Molecular Formula:
- C48H48F2N10O5
- Molecular Weight:
- 882.97 g/mol
- CAS Number:
- 2212020-52-3
- PubChem CID:
- 137319706
- Synonyms:
- LY3502970, LY-3502970, OWL-833, GLP-1 Receptor Agonist 1
- Purity:
- ≥99% (HPLC)
- Storage Conditions:
- Store away from heat and moisture
- Physical Appearance:
- Capsules
- Quality Verification:
- Third-party tested by certified laboratory
- Manufacturing Standard:
- USA-made, pharmaceutical-grade, GMP compliant
- Intended Application:
- In vitro research applications only
