Product Description
PE-22-28 is a synthetic heptapeptide analog derived from spadin, a naturally occurring peptide fragment of the sortilin protein. This shortened seven-amino-acid sequence represents the most active region of spadin and acts as a potent TREK-1 (TWIK-related potassium channel) inhibitor with an IC50 value of 0.12 nM.
Research investigations have examined PE-22-28 peptide in studies of two-pore potassium channel activity, serotonergic neuron firing rates, neurogenesis and synaptogenesis pathways, and CREB signaling mechanisms in neurological models. The compound is used in controlled laboratory environments for investigating mood regulation pathways, hippocampal neurogenesis, BDNF expression modulation, and neuroprotective mechanisms in cellular studies.
Supplied as pharmaceutical-grade spray with third-party verified purity testing for qualified research institutions conducting in vitro research applications only.
Our Product Quality Guarantee
Every Limitless Biotech Premium Lyophilized compound undergoes comprehensive independent third-party testing, including HPLC purity, sterility, endotoxin, and identity verification, as part of our systematic quality protocols.
Buy PE-22-28 Peptide From Limitless Biotech
Limitless Biotech provides USA-manufactured PE-22-28 for sale with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.
- Sequence:
- Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR)
- Molecular Formula:
- C35H55N11O9
- Molecular Weight:
- 773.89 g/mol
- CAS Number:
- 1801959-12-5
- Synonyms:
- PE22-28, PE2228, TREK-1 Inhibitor, Spadin Analog
- Purity:
- ≥99% (HPLC)
- Presentation:
- Glass Spray Bottle
- Shelf Life:
- 36 months from date of manufacture when stored properly
- Quality Verification:
- Third-party tested by certified laboratory
- Manufacturing Standard:
- USA-made, pharmaceutical-grade, GMP compliant
- Application:
- In vitro research applications only (RUO)
At Limitless Biotech, we provide comprehensive Certificates of Analysis (COAs) for all of our research-only peptides to ensure transparency, purity, and quality in every batch. Each COA includes detailed analytical data that allows researchers to verify identity, concentration, and integrity, supporting reliable and reproducible scientific work. Our commitment to rigorous testing helps researchers move forward with confidence in the materials they use.
Lyophilized PE-22-28 #1149 Purity COALyophilized PE-22-28 #1149 Updated Purity COALyophilized PE-22-28 #1149 Endotoxin COALyophilized PE-22-28 #1149 Sterility COA
