Synthetic p53-penetratin peptide analog for HDM-2 binding research and pancreatic cancer cell membrane interaction studies.
Product Description
PNC-28 is a synthetic 27-amino-acid chimeric peptide containing a shorter HDM-2 binding domain derived from p53 tumor suppressor protein (residues 17-26) fused to the same cell-penetrating peptide (CPP) sequence used in PNC-27. This membrane-active peptide represents a truncated analog that lacks the first five amino acids of PNC-27's p53 domain while retaining selective cytotoxic activity against cancer cells.
Research investigations have examined PNC-28 in studies of HDM-2/p53 protein interactions, pancreatic cancer cell necrosis mechanisms, transmembrane pore formation, and penetratin-mediated cell entry pathways. The compound is used in controlled laboratory environments for investigating anticancer peptide structure-activity relationships, membrane disruption mechanisms, and selective tumor cell targeting in various cancer cell lines including pancreatic, ovarian, and breast cancer models.
Supplied as pharmaceutical-grade lyophilized powder with third-party verified purity testing for qualified research institutions conducting in vitro research applications only.
Our Product Quality Guarantee
Every Limitless Biotech Premium Lyophilized compound undergoes comprehensive independent third-party testing, including HPLC purity, sterility, endotoxin, and identity verification, as part of our systematic quality protocols.
Buy PNC-28 Peptide From Limitless Biotech
Limitless Biotech provides USA-manufactured PNC-28 peptide for sale with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.
- Sequence:
- Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly (27 amino acids)
- Molecular Formula:
- C164H255N47O37S
- Molecular Weight:
- 3509.13
- CAS Number:
- 392661-17-5
- Synonyms:
- PNC28, PNC 28, p53 17-26 penetratin peptide
- Purity:
- ≥99% (HPLC)
- Solubility:
- Soluble in sterile water, can be further diluted in aqueous solutions
- Storage Conditions:
- Store lyophilized at -20°C; reconstituted: 4°C for 2-7 days, -20°C for long-term storage
- Physical Appearance:
- White lyophilized powder
- Shelf Life:
- 36 months from date of manufacture when stored properly
- Quality Verification:
- Third-party tested by certified laboratory
- Manufacturing Standard:
- USA-made, pharmaceutical-grade, GMP compliant
- Intended Application:
- In vitro research applications only
