*Includes complimentary 0.5% Acetic Acid reconstitution solution due to special solubility requirements. Not intended for other products.
Thymosin Alpha 1-RGDR (Tα1-RGDR)
Tα1-RGDR combines the immunomodulatory properties of Thymosin Alpha 1 with tumor-targeting RGDR sequence through a flexible GGGG linker. This 36-amino acid modified peptide binds selectively to integrin αvβ3 and Neuropilin-1 (NRP-1) receptors overexpressed on tumor cells and vascular endothelium.
The RGDR motif contains both the RGD integrin-binding sequence and a C-terminal R/KXXR/K motif for NRP-1 recognition. Research in mouse models shows Tα1-RGDR targets tumor tissue more efficiently than unmodified Tα1 while maintaining immune system activation through CD4+ and CD8+ T cell upregulation.
Studies demonstrate applications in non-small cell lung cancer, melanoma, and other solid tumor models where integrin αvβ3 expression is elevated.
For in vitro research applications only.
Our Product Quality Guarantee
Every Limitless Biotech Standard Non-Lyophilized compound undergoes independent third-party HPLC purity testing as part of our systematic quality protocols.
- Sequence:
- Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-Gly-Gly-Gly-Arg-Gly-Asp-Arg
- Structure:
- Thymosin Alpha 1 (28 aa) + GGGG linker (4 aa) + RGDR targeting motif (4 aa)
- Total Amino Acids:
- 36 amino acids
- Molecular Formula:
- C167H279N49O67S (approximate)
- Molecular Weight:
- ~3821 g/mol
- Targeting Motifs:
- RGDR (integrin αvβ3 binding), C-terminal R/KXXR/K motif (NRP-1 binding)
- Synonyms:
- Thymosin Alpha 1-RGDR, Tα1-RGDR, Modified Thymosin Alpha 1
- Purity:
- ≥99% (HPLC)
- Solubility:
- Soluble in sterile water
- Storage Conditions:
- Store at ≤-20°C, tightly sealed, away from heat and moisture
- Physical Appearance:
- White lyophilized powder
- Shelf Life:
- 36 months from date of manufacture when stored properly
- Quality Verification:
- Third-party tested by certified laboratory
- Manufacturing Standard:
- USA-made, pharmaceutical-grade, GMP compliant
- Intended Application:
- In vitro research applications only
